The spleen is the principal organ affected. Depending upon the duration of the infection and the patient‘s resistance, the spleen may undergo varying degrees of enlargement up to 1,000gm or more. During the acute stage of the infection, the splenic enlargement is moderate and the substance hemorrhagic. The capsule is thin, predisposing to rupture. As the disease becomes more chronic, there is increased fibrosis and cellularity, creating a solid enlargement. The capsule is thickened, and on crosssection the splenic substance is brown to gray-black and often has the consistency of dried cake ague cake. icd-10 training. will help you to do collections and also the pending amounts from the patients.
